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Consequently, inhibiting ACSL4 expression represents an important direction in ferroptosis research ( The final step of PUFA-PE peroxidation requires lipoxygenase catalysis, suggesting a potential role for these enzymes in ferroptosis induction

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These probes emit fluorescence upon oxidation, allowing real-time monitoring of ROS levels in various cellular compartments

DMT1 is responsible for the uptake of Fe 2+ into cells, which is essential for various physiological processes, including the generation of ROS that can trigger ferroptosis

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